An efficient one-pot synthesis of annulated pyridines utilising a directed ortho-metallation/transmetallation approach

Antony J. Davies,Karel M. J. Brands,Cameron J. Cowden,Ulf-H. Dolling,David R. Lieberman

Tetrahedron Letters（2004）

引用 22|浏览22

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摘要

The ortho-alkylation of Boc-protected aminopyridines with α,ω-dihaloalkanes followed by in situ cyclisation, resulted in the corresponding annulated pyridine derivatives in good to excellent yields.

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关键词

Ring annulation,Directed ortho-metallation,Transmetallation,Aminopyridines

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