Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a.

Kenichi Onda,Takayuki Suzuki,Ryota Shiraki,Yasuhiro Yonetoku,Kenji Negoro,Kazuhiro Momose,Naoko Katayama,Masaya Orita,Tomohiko Yamaguchi,Mitsuaki Ohta,Shin-ichi Tsukamoto

Bioorganic & Medicinal Chemistry（2008）

引用 28|浏览6

暂无评分

摘要

5-Chloro-N-[4-(1,2-dihydroxyethyl)phenyl]-1H-indole-2-carboxamide and its pyridine analog are potent inhibitors of human liver glycogen phosphorylase a (hLGPa) that binds in a solvent cavity at the hLGPa dimer interface.

查看译文

关键词

Glycogen phosphorylase,Hepatic glucose output,Diabetes,Crystallographic determination

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要