BIOLOGICAL APPLICATIONS OF MULTIFUNCTIONAL MAGNETIC NANOWIRES
msra(2007)
摘要
Nanoscale magnetic particles are playing an increasingly important role as tools in biotechnology and medicine, as well as for studying biological systems. With appropriate surface functionalization, they enable the selective application of magnetic forces to a wide range of cells, subcellular structures, and biomolecules, and have been applied to or are being developed for areas including magnetic separation, magnetic biosensing and bioassays, drug delivery and therapeutics, and probes of the mechanical and rheological properties of cells [1–10]. Despite these successes, however, the structure of the magnetic particles in common use limits the range of potential applications. Most biomagnetic particles available today are spherical, with either (a) a “core-shell” structure of concentric magnetic and nonmagnetic layers or (b) magnetic nanoparticles randomly embedded in a nonmagnetic matrix [2, 11]. These geometries constrain the range of magnetic properties that can be engineered into these particles, as well as their chemical interactions with their surroundings, because such particles typically carry only a single surface functionality. A new and more versatile approach is to use asymmetric, multisegment magnetic nanoparticles, such as the metal nanowires shown in Figure 1.1.
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