Microwave-Assisted Transformation of Esters into Hydroxamic Acids
SYNTHESIS-STUTTGART(2007)
摘要
A general, mild and efficient procedure with which to access hydroxamic acids, in good yields and purity, is reported. Esters are used as substrates and reacted with hydroxylamine, in the presence of a base, under microwave activation. The method has been successfully applied to enantiomerically pure esters without loss of stereochemical integrity.
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关键词
esters,chemoselectivity,hydroxamic acid,microwave,reactions,metalloproteinases
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