Anti-inflammatory activity profile of JANEX-1 in preclinical animal models

Bioorganic & Medicinal Chemistry, pp. 1287-1298, 2008.

Cited by: 8|Views2


We examined the biologic activity of the rationally designed JAK3 inhibitor, JANEX-1, in several cellular and animal models of inflammation. Notably, JANEX-1 exhibited potent anti-inflammatory activity in each of these preclinical models, including mouse models of peritonitis, colitis, cellulitis, and systemic inflammatory response syndro...More



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