Synthesis and evaluation of bioactive naphthoquinones from the Brazilian medicinal plant, Tabebuia avellanedae.

Mitsuaki Yamashita,Masafumi Kaneko,Harukuni Tokuda,Katsumi Nishimura,Yuko Kumeda,Akira Iida

Bioorganic & Medicinal Chemistry（2009）

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摘要

Four chiral naphtho[2,3-b]furan-4,9-diones including 1 and 2 found in the inner bark of Tabebuia avellanedae were synthesized and their biological activities such as antiproliferative, cancer chemopreventive and antimicrobial activity were examined.

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关键词

Stereoselective synthesis,Antiproliferative activity,Naphtho[2,3-b]furan-4,9-dione,Cancer chemopreventive activity,Tabebuia avellanedae,Antimicrobial activity

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