Synthesis and biological activity of N-aryl-2-aminothiazoles: potent pan inhibitors of cyclin-dependent kinases

Raj N. Misra,Hai-yun Xiao,David K. Williams,Kyoung S. Kim,Songfeng Lu,Kristen A. Keller,Janet G. Mulheron,Roberta Batorsky,John S. Tokarski,John S. Sack,S.David Kimball,Francis Y. Lee,Kevin R. Webster

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要

N-Aryl-2-aminothiazoles (structure above) were prepared and found to be inhibitors of CDK1/CDK2/CDK4 in vitro. Modification of the aryl group afforded analogues with in vivo anticancer activity.

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关键词

cyclin dependent kinase,biological activity

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