Cyclin D1 is frequently overexpressed in microsatellite unstable colorectal cancer, independent of CpG island methylator phenotype.

K Nosho, T Kawasaki,A T Chan, M Ohnishi, Y Suemoto,G J Kirkner,C S Fuchs,S Ogino

HISTOPATHOLOGY（2008）

引用 37|浏览19

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摘要

Cyclin D1 activation is associated with MSI and inversely with p21 loss in colorectal cancers. Cyclin D1 may play an important role in the development of MSI-high tumours, independent of CIMP status.

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关键词

CCND1,CDKN1A,CIMP,colon cancer,CpG island methylator phenotype,cyclin,DNA methylation,microsatellite instability,p21

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