Tolerability of switching from donepezil to memantine treatment in patients with moderate to severe Alzheimer's disease

International journal of geriatric psychiatry, Volume 23, Issue 9, 2008, Pages 979-981.

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Abstract:

Memantine has shown cognitive, functional, and behavioural benefits in Alzheimer's disease (AD) studies. An 8-week, randomised, double-blind study in patients with moderate to severe AD (DSM-IV -TR criteria and an MMSE ≤ 18) assessed the tolerability of switching AD patients, in whom there was doubt about the continued efficacy of donepez...More

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