Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 by plant extracts used as traditional antidiabetic medicines.

Elevated glucocorticoids are a key risk factor for metabolic diseases, and the glucocorticoid-activating enzyme 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) represents a promising therapeutic target. We measured the potential of six traditional antidiabetic medicinal plants extracts to inhibit 11β-HSD1 activity and glucocorticoid receptor (GR) activation in transfected HEK-293 cells. Leave extracts of Eriobotrya japonica preferentially inhibited 11β-HSD1 over 11β-HSD2. Extracts of roasted but not native coffee beans preferentially inhibited 11β-HSD1 over 11β-HSD2, emphasizing the importance of sample preparation. Thus, natural compounds inhibiting 11β-HSD1 may contribute to the antidiabetic effect of the investigated plant extracts.