Efficient Preparation of Medium Ring Oxygen Heterocycles

Atsuko Nishiguchi,Tomomi Ikemoto,Tatsuya Ito,Shotaro Miura,Kiminori Tomimatsu

HETEROCYCLES（2007）

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摘要

We achieved efficient preparation of medium ring oxygen heterocycles (1), 1-benzoxepines and 1-benzoxocines, by applying intramolecular Claisen-type condensation in dialkyl carbonate with metal alcoholate. Furthermore, we accomplished the preparation of 2,3-dihydro-l-benzoxepin-4-carboxylate intermediate (1e) for orally active CCR5 antagonists by this method.

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