Chimpanzee/human mAbs to vaccinia virus B5 protein neutralize vaccinia and smallpox viruses and protect mice against vaccinia virus

Proceedings of the National Academy of Sciences of the United States of America, Volume 103, Issue 6, 2006, Pages 1882-1887.

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binding affinityamino acidglycoproteinamino acid sequenceheavy chainMore(1+)

Abstract:

Chimpanzee Fabs against the B5 envelope glycoprotein of vaccinia virus were isolated and converted into complete mAbs with human gamma 1 heavy chain constant regions. The two mAbs (8AH8AL and 8AH7AL) displayed high binding affinities to B5 (Kd of 0.2 and 0.7 nM). The mAb 8AH8AL inhibited the spread of vaccinia virus as well as variola vir...More

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