Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

The design, synthesis, and biochemical evaluation of mechanism-based OSB-CoA synthetase inhibitors is reported.

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关键词

Acyl-CoA synthetase,Mycobacterium tuberculosis,Staphylococcus aureus,Mechanism-based inhibitor,Antibiotic

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