Synthesis, biological evaluation, and pharmacokinetic study of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives as VLA-4 antagonists.

Jun Chiba,Gensuke Takayama,Tohru Takashi,Mika Yokoyama,Atsushi Nakayama,John J Baldwin,Edward McDonald,Kevin J Moriarty,Christopher R Sarko,Kurt W Saionz,Robert Swanson,Zahid Hussain,Angela Wong,Nobuo Machinaga

Bioorganic & Medicinal Chemistry（2006）

引用 35|浏览15

暂无评分

摘要

A series of prolyl-1-piperazinylacetic acid and prolyl-4-piperidinylacetic acid derivatives were synthesized and evaluated for their activity as VLA-4 antagonists.

查看译文

关键词

VLA-4,Integrin

AI 理解论文

溯源树

样例

生成溯源树，研究论文发展脉络

Chat Paper

正在生成论文摘要