ChemInform Abstract: Design, Synthesis, and in Vitro Biological Activity of Indole-Based Factor Xa Inhibitors.

A series of indole and carbazole based inhibitors of factor Xa (FXa) has been investigated. The most potent compound inhibits FXa with a Ki of 0.2 nM and has 900- and 750-fold selectivity over thrombin and trypsin, respectively.