Arsenic induces cell apoptosis in cultured osteoblasts through endoplasmic reticulum stress

    Toxicology and applied pharmacology, Volume 241, Issue 2, 2009, Pages 173-181.

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    grp78osteoblastarsenicosteoporosiserMore(4+)

    Abstract:

    Osteoporosis is characterized by low bone mass resulting from an imbalance between bone resorption by osteoclasts and bone formation by osteoblasts. Therefore, decreased bone formation by osteoblasts may lead to the development of osteoporosis, and rate of apoptosis is responsible for the regulation of bone formation. Arsenic (As) exists ...More

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