The isoprostane 8-epi-PGF2α is a valuable indicator of oxidative injury in human heart valves
Cardiovascular Pathology(2001)
摘要
To date, little information is available concerning oxidative injury in human cardiac valves. Therefore, we sought to investigate whether the isoprostane, 8-epi-PGF2α, a novel oxidative stress marker, is localized in aortic and pulmonary valves derived from explanted hearts of patients suffering from idiopathic dilative cardiomyopathy (IDC). By using semiquantitative immunohistochemistry, we demonstrated that 8-epi-PGF2α is localized in both valves with pulmonary valves accumulating more of this isoprostane compared to aortic valves (36.69±12.04% vs. 31.54±11.49%, P<.05). These results were confirmed by a radioimmunoassay (RIA) analysis showing a similar, but not significant, difference between the two valves (288.50±72.18 pg/mg protein in the pulmonary valves and 267.30±58.77 pg/mg protein in aortic valves, P=.09). Considering the data presented in this study, we suggest that 8-epi-PGF2α is a valuable indicator of oxidative injury in human semilunar valves.
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关键词
Isoprostane,Idiopathic dilative cardiomyopathy,Aortic and pulmonary valves,Oxidative stress marker
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