Synthesis and anti-HCV activity of a new 2'-deoxy-2'-fluoro-2'-C-methyl nucleoside analogue.

Weidong Hu,Ping'an Wang,Chuanjun Song,Zhenliang Pan,Qiang Wang,Xiaohe Guo,Xuejun Yu,Zhenhua Shen,Shuyang Wang,Junbiao Chang

Bioorganic & Medicinal Chemistry Letters（2010）

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摘要

2′-Deoxy-2′-fluoro-2′-C-methyl nucleoside analogue 4 was designed and synthesized. Initial biological studies indicated that this compound showed promising activity against HCV replication.

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关键词

2′-Deoxy-2′-fluoro-2′-C-methyl nucleoside,Anti-HCV activity

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