Cross-species comparison of in vivo PK/PD relationships for second-generation antisense oligonucleotides targeting apolipoprotein B-100
Biochemical Pharmacology（2009）
摘要
Similar exposure-response relationships of ISIS 301012 in human ApoB transgenic mice and in humans.
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关键词
ASO,ApoB-100,VLDL-C,IDL-C,LDL-C,HF-fed,IACUC,s.c.,i.p.,ELISA,LLOQ,CGE,SPE,MOE
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