Malarial pigment enhances heat shock protein–27 in THP–1 cells: new perspectives for in vitro studies on monocyte apoptosis prevention
Asian Pacific Journal of Tropical Medicine(2010)
摘要
Conclusions Present data show that HZ prevents cell apoptosis and enhances the expression of anti-apoptotic HSP-27 in THP-1 cells, confirming the previous evidences obtained from HZ-fed immunopurified monocytes. Since the use of a stable cell line is pivotal to perform HSP-27 silencing experiments, monocytic THP-1 cells could be a good candidate line for such an approach, which is heavily required to clarify the role of HSP-27 in survival of impaired HZ-fed monocytes during falciparum malaria.
更多查看译文
关键词
Hemozoin,Plasmodium falciparum,Malaria,Monocyte,THP-1 cells,Phagocytosis,Apoptosis,Heat shock protein-27
AI 理解论文
溯源树
样例
生成溯源树,研究论文发展脉络
Chat Paper
正在生成论文摘要