Distinct prion proteins in short and long scrapie incubation period mice

Cell, Volume 51, Issue 4, 1987, Pages 651-662.

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pppolymorphism geneticsinbred straincomparative studypolymorphismMore(2+)

Abstract:

The Prn-i gene, controlling scrapie incubation period, is linked to or congruent with the murine prion protein (PrP) gene, Prn-p. In prototypic mouse strains with long (l/Ln) and short (NZW) incubation periods, Prn-p transcription is initiated at similar multiple sites. The predicted NZW and l/Ln PrP proteins differ at codons 108 and 189....More

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