The Design Of (-)-(S)-2-Nitrooxyethyl 1,4-Dihydro-2,6-Dimethyl-3-Nitro-4-(2-Trifluoromethylphenyl)Pyridine-5-C Arboxylate: A Cardioselective Positive Inotropic Derivative Of Bay K 8644

The title compound, (-)-(S)-9, is a novel cardioselective calcium channel modulator that exhibits a calcium channel agonist effect on heart, a weak calcium channel antagonist effect on smooth muscle, and releases nitric oxide in vitro. (-)-(S)-9 is a useful lead-compound for the design of positive inotropic agents to treat congestive heart failure, and to study the structure-function relationship of calcium channel modulation. (C) 1999 Elsevier Science Ltd. Ail rights reserved.