Resistance to moloney murine sarcoma virus-induced tumorigenesis in NK-deficient beige mice

C57BL/6J- bg J bg bg mice are reported to be less susceptible to tumor induction by threshold doses of Moloney murine sarcoma virus than their +/ bg littermates, and there are no significant differences between bg bg and +/ bg mice in which tumors were induced with respect to tumor latency, size, and regression rate. The difference in tumor frequency cannot be accounted for by M-MSV boosting of activity in bg bg mice or by depression of activity in +/ bg animals.