Prevalidation of in vitro continuous flow exposure systems as alternatives to in vivo inhalation safety evaluation experimentations: outcome from MAAPHRI-PCRD5 research program.

Jean-Paul Morin,Virginie Hasson,Mamadou Fall,Eleni Papaioanou,David Preterre,Frantz Gouriou,Veronika Keravec,Athanasios Konstandopoulos,Frédéric Dionnet

Experimental and Toxicologic Pathology（2008）

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摘要

Diesel engine emission aerosol-induced toxicity patterns were compared using both in vitro (organotypic cultures of lung tissue) and in vivo experimentations mimicking the inhalation situation with continuous aerosol flow exposure designs.

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关键词

In vitro alternatives,Inhalation toxicology,Cell cultures,Lung,Aerosol exposure,Diesel exhausts,Oxidant stress,Inflammation

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