Influence of concomitant food intake on the excretion of orally administered myo-inositol hexaphosphate in humans.

myo-Inositol hexaphosphate (InSP6) widely occurs in plant seeds. At present, some important benefits of InSP6 for human health have been described. The purpose of this study was to find the best condition for the optimum absorption of orally administered InSP6, evaluated by InsP(6) urinary excretion. The influence of different stomach conditions (empty, empty with an alkalinizing agent, and full stomach) on the effects of oral administration of InSP6 and its urinary excretion was investigated in six healthy subjects on an InSP6-poor diet, given 400 mg of calcium/magnesium salt of InSP6 as a single dose. The basal urinary excretion of InSP6 on an InSP6-poor diet (50.91 +/- 15.09 mu g) was significantly lower than that found when an InSP6-normal diet was consumed (100.09 +/- 26.42 mu g) (P < .05). No differences were observed in the areas under the curve of accumulated excretion at 8 hours among the three different stomach conditions studied, suggesting that the overall InSP6 absorption took place independently of the stomach state (full or fasted) and indicating that the InSP6 absorption also takes place during the intestinal transit. Thus, if InSP6 supplements of vegetal origin are consumed to maintain the optimum InSP6 levels needed for a healthy status, these supplements can be consumed either during or between meals with the same efficacy.