Conversion of acyclic nonpeptide CCK antagonists into CCK agonists

Gavin C. Hirst,Kennedy L. Queen,Elizabeth F. Sugg,Timothy M. Willson

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS（1997）

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摘要

The CCK antagonists RP 69758 and (R)-lorglumide were converted into CCK agonists by the introduction of an N-isopropylanilide agonist "trigger." The common structural features of these ligands suggest that nonpeptide agonists and antagonists bind to a common site in the CCK receptor. (C) 1997 Elsevier Science Ltd.

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