Discovery of new binding elements in DPP-4 inhibition and their applications in novel DPP-4 inhibitor design.

Gui-Bai Liang,Xiaoxia Qian,Tesfaye Biftu,Suresh Singh,Ying-Duo Gao,Giovanna Scapin,Sangita Patel,Barbara Leiting,Reshma Patel,Joseph Wu,Xiaoping Zhang,Nancy A Thornberry,Ann E Weber

Bioorganic & Medicinal Chemistry Letters（2008）

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摘要

The newly discovered aromatic fluorine H-bond and other binding elements in the DPP-4 inhibition were successfully incorporated into novel DPP-4 inhibitors such as 20a.

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关键词

Diabetes,DPP-4 inhibitors,Fluorine H-bond

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