Alkyl-bridged substituted 8-arylquinolines as highly potent PDE IV inhibitors.

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

Potent inhibitors of the human PDE IV enzyme are described. Substituted 8-arylquinoline analogs bearing alkyl-linked side chain were identified as potent inhibitors based on the SAR described herein.

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关键词

PDE 4,COPD,Asthma,Bronchoconstriction

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