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Small molecule inhibitors of the CCR2b receptor. Part 1: Discovery and optimization of homopiperazine derivatives.

Minoru Imai,Tatsuki Shiota,Ken-ichiro Kataoka,Christine M Tarby,Wilna J Moree,Takaharu Tsutsumi,Masaki Sudo,Michele M Ramirez-Weinhouse,Daniel Comer,Chung-Ming Sun,Shinsuke Yamagami,Hiroko Tanaka,Takuya Morita,Takahiko Hada,Jonathan Greene,Doug Barnum,John Saunders,Peter L Myers,Yoshinori Kato,Noriaki Endo

Bioorganic & Medicinal Chemistry Letters（2004）

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摘要
The discovery, the lead optimization, and the structure–activity relationship of N,N′-disubstituted homopiperazines are reported.
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关键词
binding affinity,nitrogen
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