Orally active C-6 heteroaryl- and heterocyclyl-substituted imidazo[1,2-a]pyridine acid pump antagonists (APAs).

Nick Bailey,Mark J Bamford,Delphine Brissy,Joanna Brookfield,Emmanuel Demont,Richard Elliott,Neil Garton,Irene Farre-Gutierrez,Thomas Hayhow,Gail Hutley,Antoinette Naylor,Terry A Panchal,Hui-Xian Seow,David Spalding,Andrew K Takle

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

A series of novel imidazo[1,2-a]pyridine acid pump antagonists is described. Heteroaryl and heterocyclic substituents at the C-6 position were used for the optimization of developability characteristics through modulation of global physico-chemical properties.

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关键词

Acid pump antagonist,Potassium competitive acid blocker,Imidazo[1,2-a]pyridine

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