A novel antagonist of the prostaglandin E(2) EP(4) receptor inhibits Th1 differentiation and Th17 expansion and is orally active in arthritis models.

Q Chen, K Muramoto,N Masaaki,Y Ding,H Yang,M Mackey,W Li, Y Inoue,K Ackermann,H Shirota, I Matsumoto,M Spyvee,S Schiller, T Sumida,F Gusovsky, M Lamphier

BRITISH JOURNAL OF PHARMACOLOGY（2010）

引用 92|浏览15

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摘要

PGE(2) stimulates EP(4) receptors to promote Th1 differentiation and Th17 expansion and is critically involved in development of arthritis in two animal models. Selective suppression of EP(4) receptor signalling may have therapeutic value in RA both by modifying inflammatory arthritis and by relieving pain.

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关键词

PGE(2), EP4 receptor, EP4 antagonist, Th1, Th17, IFN-gamma, IL-17, IL-23, CIA, GPI-induced arthritis model

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