Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1.

M Cheung,K W Kuntz,M Pobanz,J M Salovich, B J Wilson,C W Andrews,L M Shewchuk,A H Epperly,D F Hassler,M A Leesnitzer,J L Smith, G K Smith,T J Lansing,R A Mook

Bioorganic & Medicinal Chemistry Letters（2008）

引用 14|浏览9

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摘要

The synthesis and biological activities of imidazo[5,1-f][1,2,4]triazin-2-amines (imidazotriazines) as novel polo-like kinase 1 inhibitors are reported.

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关键词

Imidazotriazine,Polo-like kinase inhibitor

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