Novel 3,4-diarylpyrazolines as potent cannabinoid CB1 receptor antagonists with lower lipophilicity

Jos H.M. Lange,Herman H. van Stuivenberg,Willem Veerman,Henri C. Wals,Bob Stork,Hein K.A.C. Coolen,Andrew C. McCreary,Tiny J.P. Adolfs,Chris G. Kruse

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

Novel 3,4-diaryldihydropyrazoles 1 as potent CB1 receptor antagonists with lower lipophilicity are described. The key change is the replacement of the arylsulfonyl group in the original series by a dialkylaminosulfonyl moiety.

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cb1 receptor

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