Tricyclic isoxazolines: Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor antagonism

J. Ignacio Andrés,Jesús Alcázar,José M. Alonso,Rosa M. Alvarez,Margot H. Bakker,Ilse Biesmans,José M. Cid,Ana I. De Lucas,Wilhelmus Drinkenburg,Javier Fernández,Luis M. Font,Laura Iturrino,Xavier Langlois,Ilse Lenaerts,Sonia Martínez,Anton A. Megens,Joaquín Pastor,Shirley Pullan,Thomas Steckler

Bioorganic & Medicinal Chemistry（2007）

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摘要

We report on the synthesis, in vitro binding and in vivo activity of R226161, identified within our series of tricyclic isoxazolines as a potential antidepressant combining 5-HT reuptake inhibition and α2 antagonism.

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关键词

Isoxazolines,α2-Adrenoceptor blockade,Serotonin uptake inhibition,Antidepressant

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