Synthesis and SAR of derivatives based on 2-biarylethylimidazole as bombesin receptor subtype-3 (BRS-3) agonists for the treatment of obesity.

A series of 2-biarylethylimidazole analogues were synthesized as BRS-3 selective agonists. Compound 9 was identified as a potent and selective BRS-3 agonist, which lowers food intake and body weight in rodents when administrated orally.