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Synthesis and structure–activity relationships of a series of (1H-pyrazol-4-yl)acetamide antagonists of the P2X7 receptor

Laura J. Chambers,Alexander J. Stevens,Andrew P. Moses,Anton D. Michel,Daryl S. Walter,David J. Davies,David G. Livermore,Elena Fonfria,Emmanuel H. Demont,Mythily Vimal,Pam J. Theobald,Paul J. Beswick,Robert J. Gleave,Shilina A. Roman,Stefan Senger

Bioorganic & Medicinal Chemistry Letters（2010）

Cited 30|Views50
Key words
P2X7,P2X7 antagonist,Lead optimisation
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