Sulfonamidolactam inhibitors of coagulation factor Xa

Joanne M. Smallheer,Shuaige Wang,Mia L. Laws,Suanne Nakajima,Zilun Hu,Wei Han,Irina Jacobson,Joseph M. Luettgen,Karen A. Rossi,Alan R. Rendina,Robert M. Knabb,Ruth R. Wexler,Patrick Y.S. Lam,Mimi L. Quan

Bioorganic & Medicinal Chemistry Letters（2008）

引用 17|浏览17

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摘要

The synthesis and SAR of N-aryl-3-(arylsulfonylamino)-piperidone inhibitors of Factor Xa is described. Compound 55 is a representative example of this series with fXa Ki=0.043nM.

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关键词

Factor Xa inhibitors,Anticoagulant,Serine protease inhibitors,Antithrombotic

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