Pyridine-3-carboxamides as novel CB2 agonists for analgesia

William L. Mitchell,Gerard M.P. Giblin,Alan Naylor,Andrew J. Eatherton,Brian P. Slingsby,Anthony D. Rawlings,Karamjit S. Jandu,Carl P. Haslam,Andrew J. Brown,Paul Goldsmith,Nick M. Clayton,Alex W. Wilson,Iain P. Chessell,Richard H. Green,Andrew R. Whittington,Ian D. Wall

Bioorganic & Medicinal Chemistry Letters（2009）

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摘要

The synthesis and biological profile of the pyridine-3-carboxamide 14a and related analogues are described.

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关键词

Analgesia,CB2 agonist,Inflammatory pain,Cannabinoid receptors,GW842166X,Structure–activity-relationships,Pharmacokinetics,Solubility,Weinreb reaction,Cytochrome P450, in vitro clearance,Hyperalgesia,Complete Freund’s Adjuvant,Bioavailability,4-Cyclopropyl-6-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-3-pyridinecarboxamide

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