Echinosporamicin, a New Antibiotic Produced byMicromonospora echinospora ssp.echinospora, LL-P175

Echinosporamicin (1), a novel antibiotic containing an aromatic polycyclic system and a piperazinone moiety, was isolated from the fermentation broth of a new strain of Micromonospora echinospora subspecies echinospora, LL-P175. The structure of this compound was determined by spectroscopic analysis by using variable-temperature NMR techniques. Compound 1 exhibited potent activity against methicillin-resistant Staphylococci and vancomycin-resistant Enterococci strains. The methyl, ethyl, and benzyl esters showed improved antibacterial activity against Streptococci.