Doxorubicin-induced cell death requires cathepsin B in HeLa cells.
Biochemical Pharmacology(2010)
摘要
The cysteine protease cathepsin B acts as a key player in apoptosis. Cathepsin B-mediated cell death is induced by various stimuli such as ischemia, bile acids or TNFα. Whether cathepsin B can be influenced by anticancer drugs, however, has not been studied in detail. Here, we describe the modulation of doxorubicin-induced cell death by silencing of cathepsin B expression. Previously, it was shown that doxorubicin, in contrast to other drugs, selectively regulates expression and activity of cathepsin B.
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关键词
Doxorubicin,Cathepsin B,Cell death
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