New pterocarpanquinones: Synthesis, antineoplasic activity on cultured human malignant cell lines and TNF-α modulation in human PBMC cells

Chaquip D. Netto,Alcides J.M. da Silva,Eduardo J.S. Salustiano,Thiago S. Bacelar,Ingred G. Riça,Moises C.M. Cavalcante,Vivian M. Rumjanek,Paulo R.R. Costa

Bioorganic & Medicinal Chemistry（2010）

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摘要

A new pterocarpanquinone (5a) was synthesized through a palladium catalyzed oxyarylation reaction and was transformed, through electrophilic substitution reaction, into derivatives 5b–d. These compounds showed to be active against human leukemic cell lines and human lung cancer cell lines.

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关键词

Naphthoquinone,Pterocarpan,Catalytic oxa-Heck reaction,Cancer,TNF-α modulation,Bioreduction

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