Identification of potent agonists of photoreceptor-specific nuclear receptor (NR2E3) and preparation of a radioligand

Scott E. Wolkenberg,Zhijian Zhao,Marianna Kapitskaya,Andrea L. Webber,Konstantin Petrukhin,Yui Sing Tang,Dennis C. Dean,George D. Hartman,Craig W. Lindsley

Bioorganic & Medicinal Chemistry Letters（2006）

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摘要

Agonists of NR2E3 (PNR, RNR) have been identified and optimized to EC50<200nM. A tritiated analogue of one agonist was prepared to aid in the development of a binding assay.

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关键词

NR2E3,PNR,RNR,Age-related macular degeneration,AMD,Nuclear receptor,Ophthalmics

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