Dual pro-drugs of 2'-C-methyl guanosine monophosphate as potent and selective inhibitors of hepatitis C virus.

Christopher McGuigan,Karolina Madela,Mohamed Aljarah,Arnaud Gilles,Srinivas K Battina,Changalvala V S Ramamurty,C Srinivas Rao,John Vernachio,Jeff Hutchins,Andrea Hall,Alexander Kolykhalov,Geoffrey Henson,Stanley Chamberlain

Bioorganic & Medicinal Chemistry Letters（2011）

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摘要

Various 6-substituted 2′-C-methylguanosines are prepared and converted to their 5′-ProTides. In almost every case the parent nucleosides are poorly active versus HCV while the ProTides are ca 100 fold more active.

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关键词

HCV,ProTide,Phosphoramidate,Nucleoside,Nucleotide,Polymerase,NS5B

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