Frequency of regulatory T cells in peripheral blood and in tumour-infiltrating lymphocytes correlates with poor prognosis in renal cell carcinoma.

Francesco Liotta,Mauro Gacci,Francesca Frosali,Valentina Querci,Gianni Vittori,Alberto Lapini,Veronica Santarlasci,Sergio Serni,Lorenzo Cosmi,Laura Maggi,Roberta Angeli,Benedetta Mazzinghi,Paola Romagnani,Enrico Maggi,Marco Carini,Sergio Romagnani,Francesco Annunziato

BJU INTERNATIONAL（2011）

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摘要

• Treg frequency is significantly higher in TIL than in pPB of patients with RCC. Tregs showed in vitro an inhibitory activity on effector T cells isolated from kidney tumours. The increase in both peripheral and intratumoral Tregs in subjects affected with RCC were associated with worse prognosis.

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关键词

CD25,Foxp3,Treg,RCC,tolerance,tumour immunity

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