The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice.

Shigemi Sasawatari,Tadashi Okamura,Eiji Kasumi, Kaori Tanaka-Furuyama,Rieko Yanobu-Takanashi,Senji Shirasawa,Norihiro Kato,Noriko Toyama-Sorimachi

Gastroenterology（2011）

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摘要

SLC15A4 promotes colitis through Toll-like receptor 9 and NOD1-dependent innate immune responses. Histidine homeostasis within intracellular compartments is important for eliciting effective innate immune responses.

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关键词

Innate Immunity,Inflammatory Bowel Disease,Animal Model,Ulcerative Colitis

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