Reduction of Δ1-pyrroline-2-carboxylic acid to proline by an escherichia coli proline auxotroph.

Mark L. Lewis,Steve L. Martin,Christine J. Rowe,John D. Sutherland,Esther J. Wilson,Martin C. Wright

Bioorganic & Medicinal Chemistry Letters（1993）

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摘要

A new synthesis of Δ1-pyrroline-2-carboxylic acid 2 and various isotopomers is described; the conversion of 2 to proline by Escherichia coli is shown to proceed by a direct reduction.

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关键词

coli proline auxotroph,escherichia coli

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