Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria.
Bioorganic & Medicinal Chemistry Letters(2004)
摘要
A series of ester and carbonate derivatives of the glycopeptide mannopeptimycin α (1) with potent activity against G(+) bacteria, including the methicillin-resistant staphylococci and vancomycin-resistant enterococci, was synthesized. The SAR data obtained from natural and semisynthetic compounds demonstrated the importance of a hydrophobic group in the terminal mannosyl moiety for antibacterial activity.
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关键词
drug resistance
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