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Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 1: design, synthesis and biological activity.

Imadul Islam,Judi Bryant,Yuo-Ling Chou,Monica J Kochanny,Wheeseong Lee,Gary B Phillips,Hongyi Yu,Marc Adler,Marc Whitlow,Elena Ho,Dao Lentz,Mark A Polokoff,Babu Subramanyam,James M Wu,Daguang Zhu,Richard I Feldman,Damian O Arnaiz

Bioorganic & Medicinal Chemistry Letters（2007）

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摘要
Optimization of 1 afforded 4i (BX-517), a potent and selective inhibitor of PDK1.
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关键词
Ser/Thr kinases,PDK1,Akt,PI3-kinase,Cancer
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