Transcription factors and mitogen-activated protein kinases as molecular targets for chemoprevention with anti-inflammatory phytochemicals.
BIOFACTORS(2004)
摘要
Chemoprevention refers to the use of nontoxic chemical substances to inhibit, reverse, or retard tumorigenesis. Numerous compounds derived from edible plants have been reported to interfere with a specific stage of the carcinogenic process. Some anti-inflammatory phytochemicals with cyclooxygenase-2 inhibitory activity have been found to exert chemopreventive properties by targeting intracellular signaling molecules (recently reviewed by Y.J. Surh, Nature Reviews Cancer, 3: 768-780, 2003). These include mitogen-activated protein kinases and transcription factors, such as NF-kappaB and AP-1.
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关键词
cyclooxygenase-2,chemoprevention,NF-kappa B,MAP kinases,phytochemicals
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