Type IIA topoisomerase inhibition by a new class of antibacterial agents

NATURE, pp. 935-U51, 2010.

Cited by: 404|Views13
WOS NATURE

Abstract:

Despite the success of genomics in identifying new essential bacterial genes, there is a lack of sustainable leads in antibacterial drug discovery to address increasing multidrug resistance. Type IIA topoisomerases cleave and religate DNA to regulate DNA topology and are a major class of antibacterial and anticancer drug targets, yet ther...More

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